REL1 with Dimethylmethoxy Chromanol contains 1% concentration of retinol encapsulated in an oil soluble liposome. Retinol is an effective anti-aging ingredient stimulating the synthesis of collagen that ultimately accumulates in the papillary dermis and increases cellular turnover. Encapsulation of retinol in liposome enhances delivery across several layers of the epidermis without skin irritation and increases stability by providing protection against exposure to light and air.
Topical application of retinoic acid results in histological improvements, such as increasing dermal collagen synthesis and blocking collagenase activity, thus preventing collagen degradation.1-3 Retinol, a precursor of endogenous retinal and retinoic acid, was recognized as an effective antiaging treatment after it was reported to induce epidermal thickening and enhance expression of cellular retinoic acid-binding protein II (CRABPII) and cellular retinol-binding protein (CRBP).4 In clinical studies, topical retinol treatment significantly improved fine wrinkles and affected markers of photoaging, including matrix metalloproteinase, collagenase, and collagen.5-6
Dimethylmethoxy chromanol is a powerful antioxidant used in cosmetical formulations,7 providing photoprotection against UVA radiation through the inhibition of reactive oxygen species generation, thus reducing premature skin aging. It also acts as a scavenger of reactive carbonyl species, inhibiting the carbonylation of the proteins involved in DNA repair and subsequently increasing cell turnover.
The combination of oils is non-comedogenic and non-greasy. The oil-based formula can reduce trans-epidermal water loss as the last step of every night skincare routine.